Ake Sjöholm Selected Research

BLX 1002

5/2014	BLX-1002 restores glucose sensitivity and enhances insulin secretion stimulated by GLP-1 and sulfonylurea in type 2 diabetic pancreatic islets.
2/2009	BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Ake Sjöholm Research Topics

Disease

19	Type 2 Diabetes Mellitus (MODY) 07/2014 - 12/2002
10	Insulin Resistance 01/2014 - 11/2004
4	Body Weight (Weight, Body) 08/2012 - 06/2006
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2014 - 02/2005
3	Obesity 01/2014 - 04/2012
3	Glucose Intolerance 01/2014 - 02/2012
3	Hyperlipidemias (Hyperlipidemia) 01/2014 - 10/2012
3	Hypertension (High Blood Pressure) 07/2008 - 02/2005
3	Coronary Disease (Coronary Heart Disease) 02/2005 - 11/2004
2	Hyperglycemia 01/2014 - 07/2006
2	Hypoglycemia (Reactive Hypoglycemia) 02/2009 - 01/2008
2	Albuminuria 07/2008 - 07/2006
2	Myocardial Infarction 06/2006 - 02/2005
2	Inflammation (Inflammations) 01/2006 - 02/2005
1	Insulinoma 07/2014
1	Weight Gain 05/2014
1	Stroke (Strokes) 04/2013
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/2013
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 04/2013
1	Atherosclerosis 11/2012
1	Morbid Obesity 10/2012
1	Down Syndrome (Down's Syndrome) 03/2009
1	Liver Failure 01/2008
1	Diabetes Mellitus 06/2006
1	Necrosis 06/2006
1	Coronary Artery Disease (Coronary Atherosclerosis) 12/2004
1	Hypercholesterolemia 11/2004

Drug/Important Bio-Agent (IBA)

11	Glucose (Dextrose)FDA LinkGeneric 01/2014 - 12/2002
7	Insulin (Novolin)FDA Link 01/2014 - 04/2004
5	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2014 - 12/2004
4	Pharmaceutical PreparationsIBA 01/2014 - 02/2005
4	Hypoglycemic Agents (Hypoglycemics)IBA 10/2012 - 01/2006
3	PalmitatesIBA 07/2014 - 10/2012
3	Metformin (Glucophage)FDA LinkGeneric 01/2014 - 10/2012
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/2008 - 01/2006
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 07/2008 - 01/2006
3	Angiotensin Receptor AntagonistsIBA 07/2008 - 01/2006
3	C-Reactive ProteinIBA 06/2006 - 02/2005
2	Fatty Acids (Saturated Fatty Acids)IBA 07/2014 - 10/2012
2	BLX 1002IBA 05/2014 - 02/2009
2	2,4-thiazolidinedione (thiazolidinedione)IBA 05/2014 - 02/2009
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2014 - 02/2009
2	Liraglutide FDA Link 01/2014 - 08/2012
2	Blood Glucose (Blood Sugar)IBA 01/2014 - 02/2012
2	LipidsIBA 10/2012 - 07/2006
2	Nonesterified Fatty Acids (NEFA)IBA 10/2012 - 07/2006
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2008 - 11/2004
2	ThiazolidinedionesIBA 10/2007 - 01/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2006 - 01/2006
2	Interleukin-6 (Interleukin 6)IBA 06/2006 - 01/2006
2	AdiponectinIBA 06/2006 - 02/2005
1	GlucocorticoidsIBA 01/2014
1	CorticosteroneIBA 01/2014
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2014
1	IncretinsIBA 01/2014
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2014
1	GalaninIBA 10/2013
1	Type II Vasoactive Intestinal Peptide ReceptorsIBA 04/2013
1	Lys(15)-Arg(16)-Leu(27)- vasoactive intestinal peptide (1-7)-GRF (8-27)IBA 04/2013
1	Neuroprotective AgentsIBA 04/2013
1	HDL CholesterolIBA 11/2012
1	Triglycerides (Triacylglycerol)IBA 11/2012
1	Vascular Endothelial Growth Factor BIBA 10/2012
1	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 04/2012
1	Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 04/2012
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 02/2012
1	TeaIBA 02/2012
1	Formaldehyde (Formol)FDA Link 03/2009
1	Hormones (Hormone)IBA 01/2009
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2008
1	Atropine FDA LinkGeneric 01/2008
1	Ethanol (Ethyl Alcohol)IBA 01/2008
1	arginine methyl esterIBA 01/2008
1	Irbesartan FDA LinkGeneric 01/2007
1	Captopril (Capoten)FDA LinkGeneric 01/2007
1	Pravastatin (Pravachol)FDA LinkGeneric 01/2007
1	ResistinIBA 06/2006
1	Biomarkers (Surrogate Marker)IBA 01/2006
1	sapropterin (tetrahydrobiopterin)FDA Link 11/2004
1	PteridinesIBA 11/2004

Therapy/Procedure

1	Therapeutics 10/2012